In silico identification of novel PKC βII inhibitors: ligand and receptor based pharmacophore modeling, virtual screening, and molecular dynamics study
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چکیده
منابع مشابه
In silico identification of novel PKC βII inhibitors: ligand and receptor based pharmacophore modeling, virtual screening, and molecular dynamics study
The Protein Kinase C bII (PKCbII) belongs to conventional class of Protein kinase C enzyme and is preferentially activated during diabetic cardiomyopathy [1]. An effective inhibition of PKCbII is the potential option to directly treat the diabetic cardiomyopathy. Till date only one selective PKCbII inhibitor, ruboxistaurin reached phase III clinical trial for diabetic complications. Thus, there...
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ژورنال
عنوان ژورنال: Journal of Cheminformatics
سال: 2012
ISSN: 1758-2946
DOI: 10.1186/1758-2946-4-s1-p45